This collection contains minutes of the Society, 1781-1975; minutes of the directors of the Corporation, 1929-1947; membership book (with signatures of early members), 1785; and names of later members. There are also deeds to the meeting house and burying ground; treasurers' accounts; reports of officers and committees; bills and receipts for constructing, maintaining, and repairing the meeting house; cancelled checks; and letters to the Society and its officers, especially Samuel Wetherill, 1883-1884.

The collection includes letters between Hutchinson and his uncle Israel Pemberton, written while Hutchinson was a student of medicine in London. There are also 12 tickets of admission to medical lectures in Philadelphia and London, including one given by William Hunter, and 3 unused cards of admission to Hutchinson's own lectures. Miscellaneous items include Hutchinson's marriage certificate; genealogical data on the Hutchinson, Hare, and Pemberton families; and stock certificates, 1857-1872, of the McKean and Elk Land and Improvement Company. Materials dated post-1793 are to and from Hutchinson family members.